Tryniszewska E A, Bańkowski E
Department of Biochemistry, Medical Academy, Białystok, Poland.
Acta Biochim Pol. 1991;38(1):123-7.
It has been found that the methylcholanthrene-induced rat fibrosarcoma contains an enzyme (probably a cathepsin) which digests type I and type III collagens in acid pH. At physiological pH no proteolytic activity against collagen was found. It may be concluded that the tumour collagen is degraded mainly by the action of cathepsin(s).
已发现甲基胆蒽诱发的大鼠纤维肉瘤含有一种酶（可能是组织蛋白酶），该酶在酸性pH值下可消化I型和III型胶原蛋白。在生理pH值下，未发现对胶原蛋白的蛋白水解活性。可以得出结论，肿瘤胶原蛋白主要通过组织蛋白酶的作用而降解。
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