Jung Jae Sik, Park Jun Sik, Kim Si Oh, Lim Dong Gun, Park Sung Sik, Kwak Kyung Hwa, Cho Jin Duck, Jeon Young Hoon
Department of Anesthesiology, Kyungpook National University Hospital, Jung-Gu, Daegu, Republic of Korea.
Otolaryngol Head Neck Surg. 2007 Nov;137(5):753-6. doi: 10.1016/j.otohns.2007.07.024.
To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
A prospective, randomized, double-blind, placebo-controlled study.
Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.
Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.
Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.
探讨咪达唑仑在中耳手术后的预防性止吐作用。
一项前瞻性、随机、双盲、安慰剂对照研究。
90例接受全身麻醉的中耳手术女性患者在麻醉诱导后静脉注射0.075 mg/kg咪达唑仑或生理盐水（每组n = 45）。在麻醉后的头24小时内评估术后恶心和呕吐的发生率及严重程度、急救止吐药的使用情况、疼痛强度以及头痛、头晕和嗜睡等副作用。
咪达唑仑组恶心和呕吐的总发生率及严重程度。需要使用急救止吐药的患者明显低于生理盐水组（P < 0.05），但两组在疼痛强度以及头痛、头晕和嗜睡等副作用方面无显著差异。
0.075 mg/kg咪达唑仑对减少中耳手术后的恶心和呕吐有效。
Zotero 插件