散发性卵巢癌中BRCA1/2和p53体细胞失活的高频率。 - Suppr

High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer.

作者信息

Zikan Michal, Janatova Marketa, Pavlista David, Pohlreich Petr

机构信息

Department of Biochemistry and Experimental Oncology, 1st Faculty of Medicine, Charles University, Prague, U Nemocnice 5, 128 53 Prague 2, Czech Republic.

出版信息

J Genet. 2007 Aug;86(2):169-71. doi: 10.1007/s12041-007-0022-y.

DOI:10.1007/s12041-007-0022-y

PMID:17968145

Abstract

摘要

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High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer.

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本文引用的文献

Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients.

J Genet. 2005 Apr;84(1):63-7. doi: 10.1007/BF02715891.

The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer.

Reprod Biol Endocrinol. 2003 Oct 7;1:72. doi: 10.1186/1477-7827-1-72.

Detection of the most frequent mutations in BRCA1 gene on polyacrylamide gels containing Spreadex Polymer NAB.

Neoplasma. 2003;50(4):246-50.

Mutations of the BRCA1 gene in hereditary breast and ovarian cancer in the Czech Republic.

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Epigenetics in cancer: implications for early detection and prevention.

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Inactivation of BRCA1 and BRCA2 in ovarian cancer.

J Natl Cancer Inst. 2002 Sep 18;94(18):1396-406. doi: 10.1093/jnci/94.18.1396.

Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer.

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Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers.

Jpn J Clin Oncol. 2002 Mar;32(3):79-84. doi: 10.1093/jjco/hyf020.

Frequency of BRCA1 dysfunction in ovarian cancer.

J Natl Cancer Inst. 2002 Jan 2;94(1):61-7. doi: 10.1093/jnci/94.1.61.

Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors.

Cancer. 2001 Aug 15;92(4):787-95. doi: 10.1002/1097-0142(20010815)92:4<787::aid-cncr1384>3.0.co;2-4.

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High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer.

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