Jakubowska Anna, Ostrowski Maciej, Kowalczyk Stanisław
Zakład Biochemii, Instytut Biologii Ogólnej i Molekularnej, Uniwersytet Mikołaja Kopemika, ul. Gagarina 9, 87-100 Toruń.
Postepy Biochem. 2007;53(2):133-42.
Recent plant genome analyses have revealed a large number of genes encoding receptor-like kinases (RLKs) in plants. Theyare transmembrane proteins structurally related to the animal tyrosine and serin/threonine families with differences in their extracellular domains. There are more than 20 classes of plant RLKs, distinguished according to their extracellular domains, which can potentially bind an array of molecules. Although the majority of these RLKs remains uncharacterized, several members of this family are known to function in a diverse biological processes including plant growth and development, self-incompatibility, hormone perception and plant-microbe interactions. Despite knowledge of RLKs functions is increasing rapidly, yet major challenges remain. These include identifying ligands that activate RLKs and characterizing downstream pathways.
最近的植物基因组分析揭示了植物中大量编码类受体激酶(RLKs)的基因。它们是跨膜蛋白,在结构上与动物酪氨酸和丝氨酸/苏氨酸家族相关,但其细胞外结构域存在差异。植物RLKs有20多个类别,根据其细胞外结构域区分,这些结构域可能结合一系列分子。尽管这些RLKs中的大多数仍未被表征,但已知该家族的几个成员在多种生物学过程中发挥作用,包括植物生长发育、自交不亲和、激素感知和植物-微生物相互作用。尽管对RLKs功能的了解正在迅速增加,但仍然存在重大挑战。这些挑战包括识别激活RLKs的配体并表征下游途径。