Bevacizumab therapy in patients with recurrent uterine neoplasms.
作者信息
Wright Jason D, Powell Matthew A, Rader Janet S, Mutch David G, Gibb Randall K
机构信息
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
出版信息
Anticancer Res. 2007 Sep-Oct;27(5B):3525-8.
BACKGROUND
Angiogenesis plays an important role in endometrial carcinogenesis. We reviewed our experience with the anti-VEGF monoclonal antibody bevacizumab for the treatment of recurrent uterine neoplasms.
PATIENTS AND METHODS
A retrospective analysis of women with recurrent uterine neoplasms treated with bevacizumab was performed.
RESULTS
A total of 11 patients were identified, 9 with epithelial endometrial carcinomas and 2 with leiomyosarcomas. All patients had multi-site disease and were heavily pretreated with a median of 3 prior chemotherapy regimens. All received bevacizumab combination therapy which was well-tolerated. Two patients had partial responses, 3 had stable disease, while 5 patients progressed. One subject was not assessable for response. The median progression-free interval was 5.4 months for the entire cohort and 8.7 months for those who achieved clinical benefit (PR or SD).
CONCLUSION
Bevacizumab was well-tolerated and displayed promising anti-neoplastic activity in patients with endometrial cancer and uterine leiomyosarcoma.
Zotero 插件