Jones Oliver A H, Cheung Victoria L
The Hopkins Building, Department of Biochemistry, University of Cambridge, Cambridge, UK.
Comp Med. 2007 Oct;57(5):436-42.
Metabolomics has been found to be applicable to a wide range of fields, including the study of gene function, toxicology, plant sciences, environmental analysis, clinical diagnostics, nutrition, and the discrimination of organism genotypes. This approach combines high-throughput sample analysis with computer-assisted multivariate pattern-recognition techniques. It is increasingly being deployed in toxico- and pharmacokinetic studies in the pharmaceutical industry, especially during the safety assessment of candidate drugs in human medicine. However, despite the potential of this technique to reduce both costs and the numbers of animals used for research, examples of the application of metabolomics in veterinary research are, thus far, rare. Here we give an introduction to metabolomics and discuss its potential in the field of veterinary science.
代谢组学已被发现适用于广泛的领域，包括基因功能研究、毒理学、植物科学、环境分析、临床诊断、营养以及生物体基因型的鉴别。这种方法将高通量样本分析与计算机辅助多变量模式识别技术相结合。它越来越多地被应用于制药行业的毒理学和药代动力学研究，特别是在人类医学中候选药物的安全性评估期间。然而，尽管这项技术有潜力降低成本和减少用于研究的动物数量，但迄今为止，代谢组学在兽医研究中的应用实例却很少。在此，我们对代谢组学进行介绍，并讨论其在兽医学领域的潜力。
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