Gutiérrez N C, García-Sanz R, San Miguel J F
Servicio de Hematología. Hospital Universitario de Salamanca. Salamanca, Spain.
Clin Transl Oncol. 2007 Oct;9(10):618-24. doi: 10.1007/s12094-007-0114-4.
Multiple myeloma (MM) is a B-cell malignancy characterised by the accumulation of clonal plasma cells (PC) in the bone marrow (BM). The molecular bases for this incurable disease have been widely investigated in the last years, and the development of modern genomic technologies has contributed to the understanding of the pathogenesis of MM. The molecular mechanisms that explain the cellular origin of myeloma cells, the cytogenetic abnormalities and their clinical implications, and the biological information provided by gene expression profiling analysis are reviewed in this paper. In addition, a molecular classification of MM in seven groups based on the relationship between gene expression profiling, chromosomal translocations and prognostic outcome is also presented. And finally, the recent hypothesis of a potential unifying event in the pathogenesis of MM, supported by cyclin D deregulation in virtually all MM tumours, will be summarised.
多发性骨髓瘤（MM）是一种B细胞恶性肿瘤，其特征是克隆性浆细胞（PC）在骨髓（BM）中积聚。在过去几年中，人们对这种无法治愈的疾病的分子基础进行了广泛研究，现代基因组技术的发展有助于理解MM的发病机制。本文综述了解释骨髓瘤细胞细胞起源的分子机制、细胞遗传学异常及其临床意义，以及基因表达谱分析提供的生物学信息。此外，还提出了基于基因表达谱、染色体易位和预后结果之间关系的MM的七组分子分类。最后，将总结最近关于MM发病机制中潜在统一事件的假说，几乎所有MM肿瘤中的细胞周期蛋白D失调都支持这一假说。
