Sharples Edward J
Department for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary, University of London, UK.
Curr Opin Crit Care. 2007 Dec;13(6):652-5. doi: 10.1097/MCC.0b013e3282f1be4b.
The kidney has the ability to restore the structural and functional integrity of the proximal tubule, which undergoes extensive epithelial cell death via necrosis and apoptosis after a prolonged ischaemic insult. This review focuses on the recent advances in this area, and discusses the possible therapeutic interventions that might be derived from these insights.
Interest has recently been focused on the possible role of bone marrow originating stem cells in endogenous repair of the injured tubule, the identification of a resident population of progenitor cells in the kidney, and the potential therapeutic role of growth factors including erythropoietin and hepatocyte growth factor to stimulate these processes.
Advances in the understanding of the early processes that initiate and control the proliferation of surviving tubular epithelium and vascular structures are ready to be translated into clinical trials in acute kidney injury.
肾脏具有恢复近端小管结构和功能完整性的能力，在长时间缺血损伤后，近端小管会通过坏死和凋亡经历广泛的上皮细胞死亡。本综述重点关注该领域的最新进展，并讨论可能基于这些见解而产生的治疗干预措施。
最近的研究兴趣集中在骨髓源性干细胞在损伤小管内源性修复中的可能作用、肾脏中祖细胞驻留群体的鉴定，以及包括促红细胞生成素和肝细胞生长因子在内的生长因子在刺激这些过程中的潜在治疗作用。
对启动和控制存活肾小管上皮细胞和血管结构增殖的早期过程的理解进展，已准备好转化为急性肾损伤的临床试验。
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