Yetkin Ozkan, Aksoy Yüksel, Turhan Hasan, In Erdal, Karahan Mukadder, Kiliç Talat, Hacievliyagil Süleyman Savaş, Günen Hakan
Department of Chest Diseases, Faculty of Medicine, Inönü University, Malatya, Turkey.
Tuberk Toraks. 2007;55(3):225-30.
In this study we included 155 subjects, 35 patients with left heart failure, 49 chronic obstructive pulmonary disease (COPD)-cor pulmonale, 26 COPD, 20 pulmonary embolism and 25 healthy subjects. Plasma BNP level in patient with left heart failure was significantly higher than COPD-cor pulmonale, COPD and control subject in respect 1167 +/- 746, 434 +/- 55, 32 +/- 36 and 32 +/- 12 pg/mL. Plasma BNP in group of cor pulmonale was higher than COPD and control subject 434 +/- 55 vs. 32 +/- 12 pg/mL. There were no difference between COPD and control subject 32 +/- 36 vs. 32 +/- 12 pg/mL. In pulmonary embolism BNP was higher than controls 357 +/- 391 vs. 32 +/- 12 pg/mL and BNP levels of massive pulmonary embolism was higher non-massive embolism 699 +/- 394 vs 166 +/- 213 pg/mL. In this study BNP levels negative correlated with EF and positive correlated with pulmonary artery pressure. We suggest that increased BNP levels are correlated with ventricular failure and BNP is diagnostic and prognostic marker of heart failure and increased right ventricular pressure contributes to elevated BNP in patients with PE.
在本研究中，我们纳入了155名受试者，其中35名左心衰竭患者、49名慢性阻塞性肺疾病（COPD）合并肺心病患者、26名COPD患者、20名肺栓塞患者以及25名健康受试者。左心衰竭患者的血浆脑钠肽（BNP）水平显著高于COPD合并肺心病患者、COPD患者及对照受试者，分别为1167±746、434±55、32±36和32±12 pg/mL。肺心病组的血浆BNP高于COPD患者及对照受试者（434±55 vs. 32±12 pg/mL）。COPD患者与对照受试者之间无差异（32±36 vs. 32±12 pg/mL）。肺栓塞患者的BNP高于对照组（357±391 vs. 32±12 pg/mL），大面积肺栓塞患者的BNP水平高于非大面积肺栓塞患者（699±394 vs 166±213 pg/mL）。在本研究中，BNP水平与射血分数（EF）呈负相关，与肺动脉压呈正相关。我们认为，BNP水平升高与心室功能衰竭相关，BNP是心力衰竭的诊断和预后标志物，右心室压力升高导致肺栓塞患者BNP升高。
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