苯并咪唑衍生物及其前体作为MDA-MB-231人乳腺癌细胞增殖抑制剂的合成、表征及评价
Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation.
作者信息
Thimmegowda N R, Nanjunda Swamy S, Kumar C S Ananda, Kumar Y C Sunil, Chandrappa S, Yip George W, Rangappa K S
机构信息
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
出版信息
Bioorg Med Chem Lett. 2008 Jan 1;18(1):432-5. doi: 10.1016/j.bmcl.2007.08.078. Epub 2007 Oct 24.
A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor.
合成了一系列新型的三取代苯并咪唑及其前体（3-7），并采用¹H NMR、LC/MS、FTIR和元素分析技术对其进行了表征。对标题化合物进行了抑制MDA-MB-231乳腺癌细胞增殖的评估。结果表明，化合物N-(4-氰基-3-(三氟甲基)苯基)-4-氟-3-硝基苯甲酰胺（3）是一种有效的抑制剂。
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