酒精与药物滥用的神经化学成像
Imaging the neurochemistry of alcohol and substance abuse.
作者信息
Martinez Diana, Kim Jong-Hoon, Krystal John, Abi-Dargham Anissa
机构信息
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box #31, New York, NY 10032, USA.
出版信息
Neuroimaging Clin N Am. 2007 Nov;17(4):539-55, x. doi: 10.1016/j.nic.2007.07.004.
Animal models of abuse and dependence have long suggested that chronic drug and alcohol exposure is associated with marked changes in neurochemistry. The development of PET and SPECT imaging now allows investigation of the effects of addiction on the neurochemistry of the human brain. This article reviews the literature of radiochemical imaging in cocaine, alcohol, heroin, methamphetamine, MDMA, and ketamine abuse and dependence.
长期以来，滥用和依赖的动物模型表明，长期接触毒品和酒精与神经化学的显著变化有关。正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）成像技术的发展，使得人们能够研究成瘾对人脑神经化学的影响。本文综述了放射性化学成像在可卡因、酒精、海洛因、甲基苯丙胺、摇头丸和氯胺酮滥用及依赖方面的文献。
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