Hsin Chung-Han, Shun Chia-Tung, Liu Chia-Ming
Department of Otolaryngology, Chung Shan Medical University Hospital and School of Medicine, Taichung, Taiwan.
Eur Arch Otorhinolaryngol. 2008 May;265(5):539-42. doi: 10.1007/s00405-007-0515-6. Epub 2007 Nov 8.
Allergic rhinitis and chronic rhinosinusitis are the most frequently encountered inflammatory reactions of the sinonasal mucosa. Nasal-associated lymphoid tissue has been suggested as an inductive site for humoral and cellular immune responses in the upper respiratory tract. Immunoglobulins are important elements in human adaptive immune responses and deficiencies of serum immunoglobulins may be associated with recurrent or refractory infections. However, the local humoral immune response to offending antigens in the nasal environment has not been well elucidated. To determine the levels of IgA and IgG subclasses antibodies in the nasal secretions of patients with allergic rhinitis and chronic rhinosinusitis, 25 patients with allergic rhinitis and 20 with chronic rhinosinusitis were included and their nasal secretions were collected to measure the levels of secretary IgA (sIgA), total IgA (tIgA), and IgG subclasses antibodies. There was a significant elevation of IgG(3) in the nasal secretions of patients with chronic rhinosinusitis. No difference was noted in the levels of sIgA, tIgA, IgG1, IgG2 and IgG4 among the three groups. The local defense mechanism of nose reacts to microorganisms and pathogenic antigens by inducing the adaptive humoral immune response to increase the amount of immunoglobulins, with IgG3 being the major up-regulated antibody.
变应性鼻炎和慢性鼻-鼻窦炎是鼻窦黏膜最常见的炎症反应。鼻相关淋巴组织被认为是上呼吸道体液免疫和细胞免疫反应的诱导部位。免疫球蛋白是人类适应性免疫反应的重要组成部分，血清免疫球蛋白缺乏可能与反复或难治性感染有关。然而，鼻环境中针对有害抗原的局部体液免疫反应尚未得到充分阐明。为了测定变应性鼻炎和慢性鼻-鼻窦炎患者鼻分泌物中IgA和IgG亚类抗体的水平，纳入了25例变应性鼻炎患者和20例慢性鼻-鼻窦炎患者，并收集他们的鼻分泌物以测量分泌型IgA（sIgA）、总IgA（tIgA）和IgG亚类抗体的水平。慢性鼻-鼻窦炎患者鼻分泌物中的IgG(3)显著升高。三组之间sIgA、tIgA、IgG1、IgG2和IgG4的水平没有差异。鼻腔的局部防御机制通过诱导适应性体液免疫反应以增加免疫球蛋白的量来应对微生物和致病性抗原，其中IgG3是主要上调的抗体。
