直肠癌治疗：改善现状。
Rectal cancer treatment: improving the picture.
作者信息
Diaz-Gonzalez Juan A, Arbea Leire, Aristu Javier
机构信息
Department of Oncology, Clinica Universitaria, Universtity of Navarra, Avda. Pio XII, 36, Pamplona 31080, Spain.
出版信息
World J Gastroenterol. 2007 Nov 28;13(44):5805-12. doi: 10.3748/wjg.v13.i44.5805.
Abstract
Multidisciplinary approach for rectal cancer treatment is currently well defined. Nevertheless, new and promising advances are enriching the portrait. Since the US NIH Consensus in the early 90's some new characters have been added. A bird's-eye view along the last decade shows the main milestones in the development of rectal cancer treatment protocols. New drugs, in combination with radiotherapy are being tested to increase response and tumor control outcomes. However, therapeutic intensity is often associated with toxicity. Thus, innovative strategies are needed to create a better-balanced therapeutic ratio. Molecular targeted therapies and improved technology for delivering radiotherapy respond to the need for accuracy and precision in rectal cancer treatment.
摘要
目前，直肠癌治疗的多学科方法已得到明确界定。然而，新的、有前景的进展正在丰富这一图景。自90年代初美国国立卫生研究院达成共识以来，又增加了一些新的特点。纵观过去十年，可看到直肠癌治疗方案发展中的主要里程碑。正在测试将新药与放疗相结合，以提高反应率和肿瘤控制效果。然而，治疗强度往往与毒性相关。因此，需要创新策略来创造更好的治疗平衡比。分子靶向治疗和改进的放疗技术满足了直肠癌治疗中对准确性和精确性的需求。
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