西咪替丁对由化合物48/80诱导的大鼠胃部损伤黏膜羟脯氨酸含量的影响。
Effect of cimetidine on the mucosal hydroxyproline content of rat gastric lesions induced by compound 48/80.
作者信息
Arisawa T, Tsukamoto Y, Goto H, Hase S, Tsuchida T, Kuroiwa M, Suzuki T, Ohara A, Segawa K, Sugiyama S
机构信息
Department of Internal Medicine, Nagoya University School of Medicine, Japan.
出版信息
Arzneimittelforschung. 1991 Oct;41(10):1058-60.
Extensive gastric mucosal lesions developed in rats after the administration of compound 48/80 at a dose of 0.75 mg/kg daily for 3 days. The hydroxyproline content of gastric mucosa was significantly increased 4 h after the last injection of compound 48/80, and subsequently decreased as the lesions healed. Treatment with cimetidine (CAS 51481-61-9) at a dose of 50 mg/kg (twice a day for 3 days) did not affect either the development or the healing of the compound 48/80-induced gastric lesions. However, the increase in mucosal hydroxyproline content was significantly reduced by treatment with cimetidine. This fact suggests that cimetidine might have an inhibitory effect on the regeneration of collagen in gastric mucosa.
大鼠每日以0.75mg/kg的剂量给予化合物48/80，连续3天，出现了广泛的胃黏膜损伤。在最后一次注射化合物48/80后4小时，胃黏膜的羟脯氨酸含量显著增加，随后随着损伤愈合而下降。以50mg/kg的剂量（每日两次，共3天）给予西咪替丁（CAS 51481-61-9）治疗，既不影响化合物48/80诱导的胃损伤的发生，也不影响其愈合。然而，西咪替丁治疗可显著降低黏膜羟脯氨酸含量的增加。这一事实表明，西咪替丁可能对胃黏膜中胶原蛋白的再生具有抑制作用。
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