前列腺体积与前列腺癌不良特征：事实而非假象
Prostate volume and adverse prostate cancer features: fact not artifact.
作者信息
Briganti Alberto, Chun Felix K-H, Suardi Nazareno, Gallina Andrea, Walz Jochen, Graefen Markus, Shariat Shahrokh, Ebersdobler Andreas, Rigatti Patrizio, Perrotte Paul, Saad Fred, Montorsi Francesco, Huland Hartwig, Karakiewicz Pierre I
机构信息
Cancer Prognostics and Health Outcomes Unit, University of Montreal, Canada.
出版信息
Eur J Cancer. 2007 Dec;43(18):2669-77. doi: 10.1016/j.ejca.2007.09.022. Epub 2007 Nov 8.
PURPOSE
A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation.
METHODS
Logistic regression models were used.
RESULTS
Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p<0.001), with higher rate of extracapsular extension (p<0.001), seminal vesicle invasion (p<0.001) and with tumor volume >3.4 cc, after accounting for age, PSA, clinical stage and year of surgery.
CONCLUSIONS
Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.
目的
最近一项前列腺癌非那雄胺化学预防试验显示，接触非那雄胺的男性中，六分区活检检测到的高级别前列腺癌（HGPCa）发生率较高，这些男性的前列腺明显小于对照组。我们在一个未接受任何形式激素治疗的大型（n = 3412）单中心根治性前列腺切除术队列中，研究了前列腺大小与前列腺癌分级和分期之间的关联。
方法
采用逻辑回归模型。
结果
在考虑年龄、前列腺特异抗原（PSA）、临床分期和手术年份后，较小的前列腺与活检时及根治性前列腺切除时较高的HGPCa发生率相关（均p < 0.001），与较高的包膜外扩展率（p < 0.001）、精囊侵犯率（p < 0.001）以及肿瘤体积>3.4 cc相关。
结论
我们的研究结果表明，小腺体中的前列腺癌从根本上比大腺体中的前列腺癌更具侵袭性。因此，前列腺癌的检测和治疗策略应考虑前列腺体积。
Zotero 插件