尿白三烯E4

Urinary leukotriene E4.

作者信息

Rabinovitch Nathan

机构信息

National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

出版信息

Immunol Allergy Clin North Am. 2007 Nov;27(4):651-64; vii. doi: 10.1016/j.iac.2007.09.004.

DOI:10.1016/j.iac.2007.09.004

PMID:17996582

Abstract

Measurement of urinary leukotriene E4 (LTE4) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene levels in specific microenvironments, such as the airway. Urinary LTE4 measurements can be used as sensitive biomarkers of exposure to asthma triggers, such as air pollution and viral infections. Recent studies suggest the potential of using urinary LTE4 concentrations as predictors of asthma control and markers of susceptibility to treatment with leukotriene receptor antagonists.

摘要

测量尿白三烯E4（LTE4）是一种灵敏且无创的方法，可用于测定全身半胱氨酰白三烯的生成以及特定微环境（如气道）中半胱氨酰白三烯水平的变化。尿LTE4测量可用作接触哮喘触发因素（如空气污染和病毒感染）的灵敏生物标志物。最近的研究表明，尿LTE4浓度有潜力作为哮喘控制的预测指标以及白三烯受体拮抗剂治疗易感性的标志物。