Kyle Robert A, Rajkumar S Vincent
Division of Hematology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Hematol Oncol Clin North Am. 2007 Dec;21(6):1093-113, ix. doi: 10.1016/j.hoc.2007.08.005.
In 1978, the term "monoclonal gammopathy of undetermined significance" (MGUS) was introduced. MGUS is defined as a serum monoclonal (M) protein less than 3.0 g/dL; less than 10% plasma cells in the bone marrow, if done; little or no M protein in the urine; and absence of lytic bone lesions, anemia, hypercalcemia or renal insufficiency. This article discusses the recognition, prevalence, natural history, and progression of MGUS. Management of the disease is discussed along with its association with other disorders. Information on smoldering multiple myeloma is included.
1978年，“意义未明的单克隆丙种球蛋白病”（MGUS）这一术语被提出。MGUS的定义为血清单克隆（M）蛋白低于3.0 g/dL；若进行检测，骨髓中浆细胞少于10%；尿液中几乎没有或不存在M蛋白；且不存在溶骨性骨病变、贫血、高钙血症或肾功能不全。本文讨论了MGUS的识别、患病率、自然史及病情进展。还讨论了该疾病的管理及其与其他疾病的关联。文中包含了关于冒烟型多发性骨髓瘤的信息。
