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骨包虫病

Osseous hydatid disease.

作者信息

Papanikolaou Athanassios

机构信息

Orthopaedic Department, Red Cross Hospital, Athanassaki 1, 11526 Athens, Greece.

出版信息

Trans R Soc Trop Med Hyg. 2008 Mar;102(3):233-8. doi: 10.1016/j.trstmh.2007.09.012. Epub 2007 Nov 9.

Abstract

Hydatid disease is still endemic in several regions worldwide and is caused in most cases by the larval form of two species of the tapeworm Echinococcus: E. granulosus and E. multilocularis. Bone involvement is rare (0.2-4%), affecting the spine in almost half of the cases. The disease is usually silent until a complication (e.g. paraplegia or pathologic fracture) occurs. Many cases are diagnosed intraoperatively. Pre-operative diagnosis is based on radiological findings and serological assays, which lack high sensitivity and specificity. A high index of suspicion is necessary for the diagnosis, especially in patients that live in or travel to sheep-raising areas where hydatid disease is endemic. The treatment of choice is surgical, following the principles of a locally malignant lesion. Chemotherapy (albendazole alone or in combination with praziquantel) is used as an adjuvant treatment or when surgery is not possible. The prognosis is often poor, especially in the spine: most patients do not recover neurologically, the mortality and complication rate is high and many cases recur, as it is often impossible to radically excise the pathologic tissue.

摘要

包虫病在世界上几个地区仍然流行,大多数情况下是由绦虫属细粒棘球绦虫和多房棘球绦虫的幼虫形式引起的。骨骼受累情况罕见(0.2 - 4%),几乎一半的病例累及脊柱。在并发症(如截瘫或病理性骨折)发生之前,该病通常没有症状。许多病例是在手术中诊断出来的。术前诊断基于影像学检查结果和血清学检测,但这些检查缺乏高敏感性和特异性。对于诊断,尤其是对于生活在或前往包虫病流行的牧羊地区的患者,必须保持高度的怀疑指数。治疗的选择是手术,遵循局部恶性病变的原则。化疗(单独使用阿苯达唑或与吡喹酮联合使用)用作辅助治疗或在无法进行手术时使用。预后通常很差,尤其是在脊柱方面:大多数患者神经功能无法恢复,死亡率和并发症发生率很高,而且许多病例会复发,因为通常无法彻底切除病变组织。

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