Matsumoto Masaaki, Ishiguro Mayuko, Ikeno Fuminori, Ikeda Mitsunori, Kamijima Reiko, Hirata Yasuhiko, Saruta Takao, Kodama Hajime
Department of Dermatology, Kochi Medical School, Kochi, Japan.
J Cutan Pathol. 2007 Dec;34 Suppl 1:47-51. doi: 10.1111/j.1600-0560.2007.00732.x.
The histological resemblance between extramammary Paget disease and Bowen disease has been described since Bowen's original article was published in 1912.
We herein describe a case of vulval primary extramammary Paget disease in a 61-year-old women with the histological features of Bowen disease.
Histological examination of a biopsy specimen showed acanthosis with full-thickness cellular atypia, focal hyperkeratosis and parakeratosis in the epidermis, and no characteristic Paget cells were observed. However, histological examination of an operative specimen revealed areas characteristic of Paget disease and Bowen disease. Overall, the areas characteristic of Bowen disease and Paget disease occupied 6% and 32% of the total operative specimen, respectively. The two areas were sharply separated. Immunohistochemical findings showed carcinoembryonic antigen to be expressed in areas containing Paget cells, but not in the areas characteristic of Bowen disease. Cytokeratin 7 (CK7) (OV-TL 12/30) and CK8 (35betaH11) were strongly expressed in both of these areas. The staining for high-molecular-weight cytokeratins was negative in both of these areas.
Our findings indicated that primary extramammary Paget disease and squamous cell carcinoma in situ arose multifocally from a common cell in the epidermis.
自1912年鲍恩的原始文章发表以来，乳腺外佩吉特病与鲍恩病之间的组织学相似性就已被描述。
我们在此描述了一例61岁女性外阴原发性乳腺外佩吉特病，其具有鲍恩病的组织学特征。
活检标本的组织学检查显示棘皮症伴全层细胞异型性，表皮局灶性角化过度和不全角化，未观察到特征性的佩吉特细胞。然而，手术标本的组织学检查发现了佩吉特病和鲍恩病的特征区域。总体而言，鲍恩病和佩吉特病的特征区域分别占手术标本总面积的6%和32%。这两个区域界限分明。免疫组化结果显示癌胚抗原在含有佩吉特细胞的区域表达，但在鲍恩病特征区域不表达。细胞角蛋白7（CK7）（OV-TL 12/30）和CK8（35βH11）在这两个区域均强烈表达。这两个区域中高分子量细胞角蛋白的染色均为阴性。
我们的研究结果表明，原发性乳腺外佩吉特病和原位鳞状细胞癌多灶性起源于表皮中的共同细胞。
Zotero 插件