金黄色葡萄球菌：皮肤免疫的一个瑕疵。

Staphylococcus aureus: a blemish on skin immunity.

作者信息

Zinkernagel Annelies S, Nizet Victor

机构信息

Department of Pediatrics, Division of Pharmacology and Drug Discovery, University of California, San Diego, La Jolla, CA 92093-0687, USA.

出版信息

Cell Host Microbe. 2007 May 17;1(3):161-2. doi: 10.1016/j.chom.2007.05.003.

DOI:10.1016/j.chom.2007.05.003

PMID:18005694

Abstract

Staphylococcus aureus is the leading cause of human skin infections. In this issue of Cell Host & Microbe, new research probes how a change in surface hydrophobicity mediated by a single S. aureus protein renders the pathogen resistant to key molecular effectors of skin innate immunity, including cationic antimicrobial peptides and fatty acid constituents of sebum. Novel treatment strategies for S. aureus infection may lie in supplementing the very same innate defense molecules to therapeutic levels.

摘要

金黄色葡萄球菌是人类皮肤感染的主要原因。在本期《细胞宿主与微生物》杂志中，一项新研究探究了由单一金黄色葡萄球菌蛋白介导的表面疏水性变化如何使该病原体对皮肤固有免疫的关键分子效应物产生抗性，这些效应物包括阳离子抗菌肽和皮脂中的脂肪酸成分。针对金黄色葡萄球菌感染的新型治疗策略可能在于将这些相同的固有防御分子补充到治疗水平。