Karathanasis Efstathios, Bhavane Rohan, Annapragada Ananth V
Chemical Engineering Department, University of Houston, Houston, TX, USA.
Int J Nanomedicine. 2007;2(3):501-13.
In an attempt to achieve post-inhalation self-regulated insulin release, we constructed a microparticle agglomerate of nano-sized liposomal particles, with the agglomeration facilitated by cross-linkages capable of cleavage by glucose. The particles exhibited a small aerodynamic diameter within the human respirable range, but a large geometric diameter that prevents macrophage uptake and clearance. Upon intratracheal instillation of the "glucose-sensitive" microparticle into the lungs of rats, hyperglycemic events triggered an acceleration of the release of insulin achieving normoglycemia shortly after "sensing" the elevated systemic glucose. This work is a demonstration of an inhalable particle with long residence times in the lungs capable of modulating insulin release based on systemic glucose levels.
为了实现吸入后胰岛素的自我调节释放，我们构建了纳米级脂质体颗粒的微粒聚集体，其团聚由可被葡萄糖裂解的交联键促进。这些颗粒在人类可吸入范围内具有较小的空气动力学直径，但具有较大的几何直径，可防止巨噬细胞摄取和清除。将“葡萄糖敏感”微粒经气管内滴注到大鼠肺中后，高血糖事件触发胰岛素释放加速，在“感知”到全身血糖升高后不久即实现血糖正常。这项工作证明了一种可在肺部长期停留的可吸入颗粒，能够根据全身血糖水平调节胰岛素释放。
