锂急性中毒期间的肾性尿崩症

[Nephrogenic diabetes insipidus during lithium acute intoxication].

作者信息

Abodo J, Seux V, Koffi-Dago P, Dalco O, Renaud-Lévy O, Tassy S, Million M, Lokrou A, Soubeyrand J, Retornaz F

机构信息

Service de médecine interne et gériatrie, hôpital de Sainte-Marguerite, 270, boulevard de Sainte-Marguerite, 13274 Marseille cedex 09, France.

出版信息

Ann Endocrinol (Paris). 2007 Dec;68(6):467-9. doi: 10.1016/j.ando.2007.05.004. Epub 2007 Nov 26.

DOI:10.1016/j.ando.2007.05.004

PMID:18031708

Abstract

Acute lithium intoxication may occur in circumstances causing kidney failure, when using lithium chronically. This situation may lead to neurological symptoms with coma, gastrointestinal disorders with diarrhea, cardiovascular symptoms with hypotension and metabolic symptoms with hypercalcemia. Nephrogenic diabetes insipidus may also develop. We report the case of a 69-year-old woman suffering from unipolar manic-depressive psychosis and treated by lithium for 10 years. This case highlights the need to monitor serum lithium levels in patients on long-term lithium regimens, especially in circumstances involving dehydration.

摘要

急性锂中毒可能发生在慢性使用锂盐且导致肾衰竭的情况下。这种情况可能会引发伴有昏迷的神经症状、伴有腹泻的胃肠道紊乱、伴有低血压的心血管症状以及伴有高钙血症的代谢症状。还可能会发展为肾性尿崩症。我们报告了一例69岁患有单相躁郁症精神病且用锂盐治疗10年的女性病例。该病例凸显了对长期接受锂盐治疗方案的患者，尤其是在出现脱水情况时，监测血清锂水平的必要性。