倦怠中的下丘脑-垂体-肾上腺轴与免疫功能。
The HPA-axis and immune function in burnout.
作者信息
Mommersteeg Paula M C, Heijnen Cobi J, Kavelaars Annemieke, van Doornen Lorenz J P
机构信息
Laboratory for Psychoneuroimmunology, Division of Perinatology and Gynaecology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands.
出版信息
Prog Brain Res. 2008;167:281-5. doi: 10.1016/S0079-6123(07)67024-1.
Burnout results from chronic work stress. Its complaints may be related to HPA-axis disturbances or changes in immune function. In our studies the salivary cortisol awakening response, day-curve, and the suppressed level after dexamethasone intake were not different in a burned-out group compared to a control group. Nor was there a change in cortisol after a treatment period. Higher levels of DHEAS and the monocyte released anti-inflammatory cytokine IL-10 were observed, however T-cell stimulated and dexamethasone inhibited cytokine release were not affected. The increased IL-10 level may be related to an increased sensitivity for infections.
职业倦怠源于长期的工作压力。其症状可能与下丘脑-垂体-肾上腺（HPA）轴功能紊乱或免疫功能变化有关。在我们的研究中，与对照组相比，职业倦怠组的唾液皮质醇觉醒反应、日曲线以及地塞米松摄入后的抑制水平并无差异。治疗期间皮质醇水平也没有变化。然而，观察到脱氢表雄酮（DHEAS）水平较高，单核细胞释放的抗炎细胞因子白细胞介素-10（IL-10）水平也较高，不过T细胞刺激和地塞米松抑制的细胞因子释放并未受到影响。IL-10水平升高可能与对感染的敏感性增加有关。
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