Gajraj Noor M
Texas Anodyne Research Institute and Sherman Pain Care, Texas, USA.
Anesth Analg. 2007 Dec;105(6):1805-15. doi: 10.1213/01.ane.0000287643.13410.5e.
Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid. It is an alpha2-delta (alpha2-delta) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the alpha2-delta subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.
普瑞巴林是一种新型合成分子，为抑制性神经递质γ-氨基丁酸的结构衍生物。它是一种α2-δ（α2-δ）配体，具有镇痛、抗惊厥、抗焦虑和调节睡眠的活性。普瑞巴林与钙通道的α2-δ亚基强效结合，导致包括谷氨酸、去甲肾上腺素、5-羟色胺、多巴胺和P物质在内的多种神经递质释放减少。在本综述中，我将讨论普瑞巴林的药理学以及疼痛管理方面现有的疗效研究。本综述将聚焦自2005年我上次综述以来普瑞巴林药理学的进展。
