[合成代谢类固醇对胸腺细胞增殖活性的影响]
[The effect of anabolic steroids on proliferative activity of thymocytes].
作者信息
Sergeev P V, Semeĭkin A V, Dukhanin A S, Solov'eva E V
出版信息
Biull Eksp Biol Med. 1991 Oct;112(10):393-5.
PMID:1804354
Abstract
Testosterone, methandrostenolone during ten-day injections to mice 50 mg/kg decrease mass, quality of DNA and 3H thymidine in Thymus. In vitro these drugs loss 3H-thymidine incorporation at 10(-5) M. Ecdysthene do not influence proliferative activity of thymocytes in vitro and thymolytyc effect in vivo. The present results indicate, that proliferative process may have a functional significance in thymolytycal effects of anabolic steroids.
摘要
对小鼠进行为期十天的注射，剂量为50毫克/千克的睾酮和甲基雄烯醇酮会降低胸腺的质量、DNA质量以及3H胸腺嘧啶核苷的含量。在体外，这些药物在10^(-5) M浓度下会抑制3H胸腺嘧啶核苷的掺入。蜕皮甾酮在体外不影响胸腺细胞的增殖活性，在体内也无胸腺溶解作用。目前的结果表明，增殖过程可能在合成代谢类固醇的胸腺溶解作用中具有功能意义。
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