Tylec Aneta, Stryjecka-Zimmer Marta, Kucharska-Pietura Katarzyna
Katedra i Klinika Psychiatrii AM w Lublinie.
Psychiatr Pol. 2007 Jul-Aug;41(4):485-93.
Amin oxydase (monoaminoxydase, MAO) is an enzyme which catalyses chemical reactions of biogenic amines. It plays a crucial role in pathogenesis of mental disorders associated with the dysfunction of the central monoaminergic systems (schizophrenia, affective disorders, some forms of alcohol dependence, and personality disorders). MAO has got two isoforms such as MAO-A and MAO-B. The genes coding of MAO are localised at the short arm of chromosome Xp11. In each sequence of genes there is a probability of functional polymorphism occurrence which leads to a variable expression or a change of MAO activity and it exerts an impact on the onset of some mental disorders, such as: schizophrenia, affective disorders, some forms of alcohol dependence, and personality and behavioural disorders. Dynamic development of psychiatric genetics may have crucial impact on considerable progress in understanding molecular background of mental disorders.
胺氧化酶（单胺氧化酶，MAO）是一种催化生物胺化学反应的酶。它在与中枢单胺能系统功能障碍相关的精神障碍（精神分裂症、情感障碍、某些形式的酒精依赖和人格障碍）的发病机制中起关键作用。MAO有两种同工型，即MAO - A和MAO - B。编码MAO的基因位于Xp11染色体的短臂上。在每个基因序列中都有可能出现功能多态性，这会导致MAO活性的可变表达或变化，并对某些精神障碍的发病产生影响，如：精神分裂症、情感障碍、某些形式的酒精依赖以及人格和行为障碍。精神遗传学的动态发展可能对理解精神障碍的分子背景取得重大进展产生关键影响。
