[Evaluation of the hemodynamic effects of the long-acting peripheral vasodilator flosequinan in patients with chronic heart failure].

The hemodynamic effects of the peripheral vasodilator flosequinan, 100 mg/day, were evaluated in 20 patients with Stage IIA-IIB (the Lang-Strazhesko-Vasilenko classification) heart failure. The doses of digoxin and diuretics were found to be stable. The right cardiac cavities and pulmonary artery were catheterized by Swan-Ganz balloon catheters. The agent was demonstrated to produced profound effects showing decreased pre- and afterload when given both in a single dose or in course therapy.