Nandkeoliar Manoj Kumar, Dharmalingam Mala, Marcus Sara Rani
Department of Biochemistry, M.S. Ramaiah Medical College, Bangalore, India.
J Pediatr Endocrinol Metab. 2007 Oct;20(10):1109-14. doi: 10.1515/jpem.2007.20.10.1109.
To study the clinical and metabolic profile of type 1 and type 2 diabetes mellitus in children and adolescents in a South Asian population.
Sixty children were recruited. They were divided into three groups: Group I--type 2 diabetes mellitus (DM2), Group II--type 1 diabetes mellitus (DM1), and Group III--healthy controls. The clinical history and biochemical parameters (HbA1c, serum insulin, C-peptide, triglycerides, total cholesterol and HDL-cholesterol) were recorded. Homeostasis model assessment for insulin resistance (HOMAIR) and quantitative insulin sensitivity check index (QUICKI) were calculated.
Children and adolescents with DM2 had a significant family history of DM and clinical features of insulin resistance, including increased body mass index, waist:hip ratio and acanthosis nigricans. They also had decreased insulin sensitivity together with dyslipidemia of metabolic syndrome, i.e. high triglyceride, high total cholesterol and low HDL-cholesterol. The presence of these predictors of cardiovascular disorders is known to contribute to morbidity and mortality. Hence, DM2 needs to be recognized early in Asian Indian children.
研究南亚人群中儿童和青少年1型和2型糖尿病的临床及代谢特征。
招募了60名儿童。他们被分为三组：第一组——2型糖尿病（DM2），第二组——1型糖尿病（DM1），第三组——健康对照。记录临床病史和生化参数（糖化血红蛋白、血清胰岛素、C肽、甘油三酯、总胆固醇和高密度脂蛋白胆固醇）。计算胰岛素抵抗的稳态模型评估（HOMAIR）和定量胰岛素敏感性检查指数（QUICKI）。
DM2儿童和青少年有显著的糖尿病家族史及胰岛素抵抗的临床特征，包括体重指数增加、腰臀比增加和黑棘皮病。他们还存在胰岛素敏感性下降以及代谢综合征的血脂异常，即高甘油三酯、高总胆固醇和低高密度脂蛋白胆固醇。已知这些心血管疾病预测指标的存在会导致发病和死亡。因此，在亚洲印度儿童中需要早期识别DM2。
