[医院中拟给新生儿使用的口服液体制剂的渗透压摩尔浓度]
[Osmolality of oral liquid dosage forms to be administered to newborns in a hospital].
作者信息
Fernández Polo A, Cabañas Poy M J, Clemente Bautista S, Oliveras Arenas M, Castillo Salinas F, Hidalgo Albert E
机构信息
Servicio de Farmacia, Area Materno-infantil, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
出版信息
Farm Hosp. 2007 Sep-Oct;31(5):311-4. doi: 10.1016/s1130-6343(07)75395-3.
OBJECTIVE
Oral administration of hypertonic solutions can contribute to intestinal damage in the initial stages of neonatal necrotizing enterocolitis. The purpose of this study is to determine the osmolality of oral liquid dosage forms used in a division of neonatology and to establish some recommendations for their dilution.
METHOD
The osmolality of 26 oral liquid dosage forms has been measured using the freezing-point depression method.
RESULTS
Oral liquid dosage forms used in the division of neonatology present an osmolality greater than 350 mOsm/kg H2O. 19.2% of all the analysed forms presented an osmolality lower than 1500 mOsm/kg H2O, 80.7% were over that figure, while 23% presented an extremely high osmolality (> 5,000 mOsm/kg H2O).
CONCLUSIONS
Knowledge of osmolality of oral liquid dosage forms in the division of neonatology enables the risk of intestinal aggression caused by enteral administration of the medication to be assessed.
目的
口服高渗溶液可在新生儿坏死性小肠结肠炎的初始阶段导致肠道损伤。本研究的目的是测定新生儿科某一科室使用的口服液体制剂的渗透压，并为其稀释制定一些建议。
方法
采用冰点降低法测定了26种口服液体制剂的渗透压。
结果
新生儿科使用的口服液体制剂的渗透压大于350 mOsm/kg H₂O。所有分析制剂中，19.2%的渗透压低于1500 mOsm/kg H₂O，80.7%高于该数值，而23%呈现极高的渗透压（>5000 mOsm/kg H₂O）。
结论
了解新生儿科口服液体制剂的渗透压有助于评估经肠道给药引起肠道损伤的风险。
Zotero 插件