一名无症状尼日利亚人狼疮抗凝物的存在情况。
Presence of lupus anticoagulant in an asymptomatic Nigerian.
作者信息
Olayemi Edeghonghon E, Bazuaye Godwin N
机构信息
Department of Haematology and Blood Transfusion, OACHS, Olabisi Onabanjo, University, PMB 2022, Sagamu, Ogun State, Nigeria.
出版信息
Afr Health Sci. 2007 Sep;7(3):182-4. doi: 10.5555/afhs.2007.7.3.182.
BACKGROUND
The lupus anticoagulant (LA) is one of the antiphospholipid antibodies (aPL), which prolong phospholipid- dependent coagulation tests by interfering with coagulation reactions that depend on protein - phospholipid complexes in vitro.
METHOD
A 25 year old 'healthy' male Nigerian was screened for the presence of any coagulation abnormality using the KCT, PT and platelet count; after volunteering for his plasma to be used in the preparation of normal pooled plasma in a study.
RESULTS
He was discovered to have a prolonged KCT, PT and normal platelet count. Based on the prolonged KCT his plasma was subjected to mixing studies with various concentration of normal pooled plasma; the KCT index was calculated and a curve was plotted. His KCT index was 1.6 and the curve convex in the left axis suggesting the presence of LA. His past medical history and physical examination were not remarkable. Three months after the initial study, a repeat KCT index was 1.4 and the subject asymptomatic.
CONCLUSION
From literature review this is the first report of LA in an asymptomatic adult Nigerian; the importance of this finding is discussed.
背景
狼疮抗凝物（LA）是抗磷脂抗体（aPL）之一，它通过在体外干扰依赖蛋白质 - 磷脂复合物的凝血反应，延长依赖磷脂的凝血试验时间。
方法
一名25岁自称“健康”的尼日利亚男性在一项研究中自愿提供血浆用于制备正常混合血浆后，使用高岭土凝血时间（KCT）、凝血酶原时间（PT）和血小板计数对其进行凝血异常筛查。
结果
发现他的KCT和PT延长，血小板计数正常。基于KCT延长，将他的血浆与不同浓度的正常混合血浆进行混合研究；计算KCT指数并绘制曲线。他的KCT指数为1.6，曲线在左轴凸起，提示存在LA。他既往病史和体格检查无异常。初次研究三个月后，重复检测KCT指数为1.4，该受试者无症状。
结论
通过文献回顾，这是关于无症状成年尼日利亚人LA的首例报告；讨论了这一发现的重要性。
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