细胞抑制药物对猪冠状动脉平滑肌细胞群体的表型特征有不同影响。
Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations.
作者信息
Prunotto Marco, Bacchetta Marc, Jayaraman Swaminathan, Galloni Marco, Van Eys Guillaume, Gabbiani Giulio, Bochaton-Piallat Marie-Luce
机构信息
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, 1211 Geneva 4, Switzerland.
出版信息
FEBS Lett. 2007 Dec 22;581(30):5847-51. doi: 10.1016/j.febslet.2007.11.060. Epub 2007 Nov 29.
We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of alpha-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.
我们研究了细胞毒性药物对猪冠状动脉纺锤形（S）和平菱形（R）平滑肌细胞（SMC）生物学活性的影响，这些活性与内膜增厚（IT）形成相关。与环孢素加雷帕霉素相比，伊马替尼以及程度较轻的姜黄素更有效地降低了S型和R型SMC的增殖以及R型SMC的迁移和尿激酶活性。伊马替尼增加了两种SMC群体中α-平滑肌肌动蛋白的表达以及S型SMC中平滑肌蛋白的表达。它降低了R型SMC中S100A4的表达。通过促进SMC的静止和分化，伊马替尼和姜黄素可能是预防和治疗再狭窄策略的有效候选药物。
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