Zannis-Hadjopoulos Maria, Yahyaoui Wafaa, Callejo Mario
McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
Trends Biochem Sci. 2008 Jan;33(1):44-50. doi: 10.1016/j.tibs.2007.09.012. Epub 2007 Nov 28.
Cruciforms are secondary DNA structures, serving as recognition signals at or near eukaryotic (yeast and mammalian) origins of DNA replication. The cruciform-binding protein is a member of the 14-3-3 protein family and binds to origins of DNA replication in a cell cycle-dependent manner. Five 14-3-3 protein isoforms (beta, gamma, epsilon, zeta and sigma) have been identified as having cruciform binding activity.
十字形结构是二级DNA结构，作为真核生物（酵母和哺乳动物）DNA复制起点处或其附近的识别信号。十字形结合蛋白是14-3-3蛋白家族的成员，以细胞周期依赖性方式与DNA复制起点结合。已鉴定出五种14-3-3蛋白亚型（β、γ、ε、ζ和σ）具有十字形结合活性。
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