Lou Benyong, Boström Dan, Velaga Sitaram P
Department of Health Science, Luleå University of Technology, Luleå S-971 87, Sweden.
Acta Crystallogr C. 2007 Dec;63(Pt 12):o731-3. doi: 10.1107/S0108270107053218. Epub 2007 Nov 24.
Norfloxacin and ciprofloxacin crystallize with phosphoric acid in aqueous solution to give the salts 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C16H19FN3O3(+) x H2PO4(-) x H2O, and 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-7-quinolyl)piperazinium dihydrogenphosphate monohydrate, C17H19FN3O3(+) x H2PO4(-) x H2O, respectively. In the crystal structures, the phosphate anions and the piperazine rings of norfloxacin or ciprofloxacin form a 12-membered supramolecular synthon, viz. R4(4)(12). The synthons R4(4)(12) and R2(2)(8) formed between adjacent phosphate anions result in the three-dimensional structures.
诺氟沙星和环丙沙星在水溶液中与磷酸结晶，分别生成盐4-(3-羧基-1-乙基-6-氟-4-氧代-1,4-二氢-7-喹啉基)哌嗪二氢磷酸盐水合物，C16H19FN3O3(+)·H2PO4(-)·H2O，以及4-(3-羧基-1-环丙基-6-氟-4-氧代-1,4-二氢-7-喹啉基)哌嗪二氢磷酸盐水合物，C17H19FN3O3(+)·H2PO4(-)·H2O。在晶体结构中，磷酸根阴离子与诺氟沙星或环丙沙星的哌嗪环形成一个12元超分子合成子，即R4(4)(12)。相邻磷酸根阴离子之间形成的合成子R4(4)(12)和R2(2)(8)导致了三维结构的形成。
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