Olausson H, Lof M, Brismar K, Lewitt M, Forsum E, Sohlstrom A
Department of Biomedicine and Surgery, Division of Nutrition, Linkoping University, Linkoping, Sweden.
Horm Res. 2008;69(2):99-106. doi: 10.1159/000111813. Epub 2007 Dec 5.
The maternal insulin-like growth factor (IGF) system is considered to be involved in fetal growth regulation. However, available data linking this system to fetal growth are contradictory and incomplete.
To measure components of the IGF system before, during and after pregnancy in healthy women and to relate these results, and their changes during pregnancy, to fetal weight (gestational week 31) and birth weight.
Serum concentrations of IGF-I, IGF-II, IGF-binding protein (IGFBP)-1, IGFBP-3 and IGFBP-3 protease activity were assessed in 23 women before conception, at weeks 8, 14, 20, 32 and 35 of pregnancy and 2 weeks postpartum. The data were analyzed using simple and multiple linear regression.
One third of the variability in fetal weight was explained by IGF-I in combination with IGFBP-3 protease activity, both assessed at gestational week 32 (p = 0.013). Birth weight was negatively correlated (r = -0.43 to -0.59) with IGFBP-1 at gestational week 20 (p = 0.041), 32 (p = 0.012) and 35 (p = 0.003).
We propose there is a finely tuned balance among the components of the IGF system, providing a means for fetal growth regulation.
母体胰岛素样生长因子（IGF）系统被认为参与胎儿生长调节。然而，将该系统与胎儿生长联系起来的现有数据相互矛盾且不完整。
测量健康女性在怀孕前、孕期和产后IGF系统的组成部分，并将这些结果及其孕期变化与胎儿体重（孕31周）和出生体重相关联。
对23名女性在受孕前、孕8周、14周、20周、32周、35周以及产后2周时的血清IGF-I、IGF-II、IGF结合蛋白（IGFBP）-1、IGFBP-3浓度和IGFBP-3蛋白酶活性进行评估。数据采用简单和多元线性回归分析。
孕32周时评估的IGF-I与IGFBP-3蛋白酶活性相结合，解释了胎儿体重三分之一的变异性（p = 0.013）。出生体重与孕20周（p = 0.041）、32周（p = 0.012）和35周（p = 0.003）时的IGFBP-1呈负相关（r = -0.43至-0.59）。
我们认为IGF系统各组成部分之间存在精细调节的平衡，为胎儿生长调节提供了一种方式。
