Meyaard Linde
Department of Immunology, University Medical Center, Utrecht 3584 EA, The Netherlands.
J Leukoc Biol. 2008 Apr;83(4):799-803. doi: 10.1189/jlb.0907609. Epub 2007 Dec 6.
The immune system protects the body from invaders such as viruses and bacteria. Immune cells must be activated in the correct context to function properly. It is critical that the receptors, costimulatory molecules, and cytokines that orchestrate this activation are carefully regulated to prevent uncontrolled inflammation and autoimmunity. Inhibitory receptors play an important role in regulation of immune cell function, usually upon interaction with ligands present on other cells. In contrast, the function of the inhibitory leukocyte-associated Ig-like receptor (LAIR)-1 can be regulated by extracellular matrix collagens. LAIR-1 is expressed on most cells of the immune system, and its function has been studied on multiple cell types. This review summarizes current literature about LAIR-1, a receptor that potentially is able to regulate multiple steps of an immune response.
免疫系统保护身体免受病毒和细菌等入侵者的侵害。免疫细胞必须在正确的环境中被激活才能正常发挥功能。协调这种激活的受体、共刺激分子和细胞因子必须受到严格调控，以防止不受控制的炎症和自身免疫。抑制性受体通常在与其他细胞上存在的配体相互作用时，在免疫细胞功能的调节中发挥重要作用。相比之下，抑制性白细胞相关免疫球蛋白样受体（LAIR）-1的功能可由细胞外基质胶原蛋白调节。LAIR-1在免疫系统的大多数细胞上表达，并且已经在多种细胞类型上研究了其功能。本综述总结了关于LAIR-1的当前文献，LAIR-1是一种可能能够调节免疫反应多个步骤的受体。
