Development of an antitumor adenosine analog, 3''-ethynyladenosine.
作者信息
Endo Yoshio, Obata Tohru, Nomura Makoto, Fukushima Masakazu, Yamada Yuji, Matsuda Akira, Sasaki Takuma
机构信息
Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):691-4. doi: 10.1080/15257770701490654.
PMID:18066881
Abstract
3'-ethynyladenosine (EAdo) was an adenosine analog with potent antitumor activity against various human tumor cells in vitro. However, EAdo was enzymatically inactivated by adenosine deaminase (ADA) in vitro and in vivo. Therefore, we synthesized two ADA-resistant EAdo derivatives (2-F-EAdo and EAdo-5'-monophosphate, EAMP) and examined their antitumor activities.
摘要
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