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基因重排作为对抗减数分裂驱动的一种防御机制。

Genetic scrambling as a defence against meiotic drive.

作者信息

Haig D, Grafen A

机构信息

Department of Plant Sciences, University of Oxford, U.K.

出版信息

J Theor Biol. 1991 Dec 21;153(4):531-58. doi: 10.1016/s0022-5193(05)80155-9.

Abstract

Genetic recombination has important consequences, including the familiar rules of Mendelian genetics. Here we present a new argument for the evolutionary function of recombination based on the hypothesis that meiotic drive systems continually arise to threaten the fairness of meiosis. These drive systems act at the expense of the fitness of the organism as a whole for the benefit of the genes involved. We show that genes increasing crossing over are favoured, in the process of breaking up drive systems and reducing the fitness loss to organisms.

摘要

基因重组具有重要影响,包括孟德尔遗传学中为人熟知的规律。在此,我们基于减数分裂驱动系统不断出现并威胁减数分裂公平性这一假说,提出关于重组进化功能的新观点。这些驱动系统以牺牲生物体整体适应性为代价,使相关基因受益。我们表明,在破坏驱动系统并减少生物体适应性损失的过程中,增加交叉互换的基因受到青睐。

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