Meningiomas are still defined as benignant tumours although 25% of those tumours will have local recurrance in the follow-up period. The WHO (2000) classification divides meningiomas in three goups: Grade 1 for conventional meningioma. Grade 2 for atypical meningioma and Grade 3 for Anaplastic meningioma. Specific histological variants of meningiomas have been included in grade 2 tumours. Clear cell, rabdoid and papillary meningiomas. We obtained 250 meningiomas from our files and we analyzed 30 inmunohistochemical markers. Several markers can be actually used as prognostic indicators in meningiomas and may allow a more individualized management of patients.