Saint-Jean O, Bérigaud S, Bouchon J P
Unité de Médecine Interne et Gériatrie, Hôpital Charles-Foix, Ivry-sur-Seine.
Ann Med Interne (Paris). 1991;142(8):563-9.
Descriptive epidemiology has demonstrated the increase with age of the number of identifiable diseases per subject. However, the clinical relevance of this polypathology varies according to the type of affliction, and all pathologies are not necessarily implicated in all morbid events. This prospective study analyzed the length of hospitalization (mean stay: 17.26 +/- 10.52 days) of 100 subjects at least 80 years old (mean age: 85.2 +/- 4.35 yr). The mean total number of recognized diseases per patients was 4.12 +/- 1.83 (range: 1-10). The mean number of diseases concerned by the hospitalization studied was 3.13 +/- 1.60 (range: 1-9). Dynamic analysis of the morbidity of these patients led to their classification into two groups: a) co-morbid patients with several diseases among which interaction is not possible; and b) polymorbid patients with several diseases able to interact. In a polymorbid patient, a disease event can occur as the result of such an interaction (leading to multiple organ failure) or the evolution of a single entity. The number of diseases concerned by the hospitalization varied significantly according to the different models of morbidity, which reflect the different types of medical activity. The lengths of the hospital stay observed did not seem to be influenced by the morbidity model, thereby indicating the existence of other factors prolonging hospitalization. The data collected supported the validity of this approach to disease in the elderly whose objective is a new description of medical activity in this population.
描述性流行病学已证明,每个个体可识别疾病的数量会随着年龄增长而增加。然而,这种多病共存情况的临床相关性因疾病类型而异,并非所有病理情况都必然与所有发病事件相关。这项前瞻性研究分析了100名至少80岁(平均年龄:85.2±4.35岁)受试者的住院时长(平均住院时间:17.26±10.52天)。每位患者确诊疾病的平均总数为4.12±1.83(范围:1 - 10种)。所研究的住院相关疾病的平均数量为3.13±1.60(范围:1 - 9种)。对这些患者发病率的动态分析将他们分为两组:a)患有多种疾病但相互之间不可能产生相互作用的共病患者;b)患有多种能够相互作用疾病的多病共存患者。在一名多病共存患者中,疾病事件可能是这种相互作用的结果(导致多器官功能衰竭),也可能是单一疾病实体的进展所致。住院相关疾病的数量根据不同的发病模式有显著差异,这些模式反映了不同类型的医疗活动。观察到的住院时长似乎不受发病模式的影响,从而表明存在其他延长住院时间的因素。所收集的数据支持了这种针对老年人疾病的研究方法的有效性,其目的是对该人群的医疗活动进行全新描述。