Kaech Stefanie, Banker Gary, Stork Phillip
Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, USA.
Sci STKE. 2007 Dec 11;2007(416):pe71. doi: 10.1126/stke.4162007pe71.
Neurons develop two types of processes, axons and dendrites, whose growth must be independently controlled. Recent research has identified the small guanosine triphosphatase Rit as a differential regulator of neurite growth. Activation of Rit enhances axonal growth, whereas inhibition of Rit promotes dendritic growth. These results imply that the reciprocal regulation of a single molecule in the same cell can achieve simultaneous regulation of axonal and dendritic growth.
神经元会形成两种突起,即轴突和树突,它们的生长必须受到独立控制。最近的研究已确定小GTP酶Rit是神经突生长的差异调节因子。Rit的激活会增强轴突生长,而抑制Rit则会促进树突生长。这些结果表明,同一细胞中单个分子的相互调节能够实现对轴突和树突生长的同步调节。