β-OH-D-亮氨酸(7)部分修饰的(-)-ternatin衍生物的合成及其对脂肪积累的抑制作用
Synthesis and inhibitory effect on fat accumulation of (-)-ternatin derivatives modified in the beta-OH-D-Leu(7) moiety.
作者信息
Shimokawa Kenichiro, Iwase Yoshiaki, Yamada Kaoru, Uemura Daisuke
机构信息
Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
出版信息
Org Biomol Chem. 2008 Jan 7;6(1):58-60. doi: 10.1039/b714710d. Epub 2007 Nov 22.
DOI:10.1039/b714710d
PMID:18075648
Abstract
An efficient synthesis of (-)-ternatin derivatives directed toward their SAR at the beta-OH-D-Leu(7) moiety and their biological activities against 3T3-L1 murine adipocytes are described.
摘要
本文描述了一种针对β-OH-D-Leu(7)部分的(-)-ternatin衍生物的高效合成方法及其对3T3-L1小鼠脂肪细胞的生物活性。
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