Lindvik Helene, Holden Lise, Løvik Martinus, Cvancarova Milada, Halvorsen Ragnhild
Voksentoppen, Department of Pediatrics, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway.
Acta Paediatr. 2008 Jan;97(1):91-5. doi: 10.1111/j.1651-2227.2007.00568.x. Epub 2007 Dec 10.
The aim of the present pilot study was to investigate to what extent children in Norway sensitized to lupin had clinical lupin allergy, and to compare sensitization to lupin with sensitization to other legumes.
Thirty-five children with food allergy referred to a national referral hospital were evaluated with skin prick test (SPT) and analysis of serum-specific IgE to lupin, peanut, pea and soy. The children with positive SPTs to lupin were offered oral food challenges with lupin flour.
Fifteen children (43%) had positive SPT and 17 children (49%) had serum-specific IgE to lupin. Ten SPT-positive children underwent oral food challenges and one experienced an allergic reaction to lupin flour. This child was one of six challenged children with IgE antibodies to peanut >15 kU(A)/L. There was a strong relationship between positive SPT to lupin flour and positive SPT to soy and between positive SPT to lupin and specific IgE to soy, pea and peanut.
Children with sensitization to lupin are not likely to have a clinical lupin allergy. Avoidance of lupin on the basis of lupin sensitization or peanut allergy would lead to unnecessarily strict diets. Food challenge is currently necessary to diagnose lupin allergy.
本初步研究旨在调查挪威对羽扇豆致敏的儿童患临床羽扇豆过敏的程度，并比较对羽扇豆的致敏情况与对其他豆类的致敏情况。
对转诊至一家国家转诊医院的35名食物过敏儿童进行了皮肤点刺试验（SPT），并分析了其血清中针对羽扇豆、花生、豌豆和大豆的特异性IgE。对羽扇豆皮肤点刺试验呈阳性的儿童接受了羽扇豆面粉口服食物激发试验。
15名儿童（43%）皮肤点刺试验呈阳性，17名儿童（49%）血清中存在针对羽扇豆的特异性IgE。10名皮肤点刺试验阳性的儿童接受了口服食物激发试验，其中1名儿童对羽扇豆面粉出现过敏反应。该儿童是6名对花生IgE抗体>15 kU(A)/L的接受激发试验的儿童之一。对羽扇豆面粉皮肤点刺试验阳性与对大豆皮肤点刺试验阳性之间，以及对羽扇豆皮肤点刺试验阳性与对大豆、豌豆和花生的特异性IgE之间存在密切关系。
对羽扇豆致敏的儿童不太可能患有临床羽扇豆过敏。基于羽扇豆致敏或花生过敏而避免食用羽扇豆会导致不必要的严格饮食。目前诊断羽扇豆过敏需要进行食物激发试验。
