Passamonti Basilio, Bulletti Simonetta, Camilli Maria, D'Amico Maria Rosaria, Di Dato Eugenio, Gustinucci Daniela, Martinelli Nadia, Malaspina Morena, Spita Nicoletta
Department of Clinical Pathology, Cytology Center, Perugia, Italy.
Acta Cytol. 2007 Nov-Dec;51(6):865-71. doi: 10.1159/000325862.
To evaluate the FocalPoint Location-Guided Screening (FPGS) performance in computer-assisted primary screening of Papanicolaou-stained cervicovaginal smears.
A total of 37,306 routine consecutive conventional Pap slides were prospectively processed on the FPGS. Each slid designated by the instrument as Review was reported according to results obtained using a GS Review Station. Subsequently, all slides under went conventional manual rapid screening and reported results were compared.
Of the slides initially submitted to the FPGS, 34,004 (91.15%) were qualified for scanning. Within these slides, the system classified 7,399 (21.8%) as needing No Further Review and ranked to Review the remaining 26,605 (78.2%). Of the 418 cellular abnormalities found, 409 were classified for Review by FPGS and 9 minor grade lesions were classified in the "No Further Review" population. Overall, 352 (86%) of atypical squamous cell (ASC)+ were ranked in high-score quintiles, including 96 (94%) of the 102 high-grade squamous intraepithelial lesion (HSIL) or worse. Location-guided software identified cellular abnormalities, in the automatically selected fields of view, in 378 (92%) of the ranked abnormal slides, showing a sensitivity > 95% on SILs.
Slide ranking and location-guided screening features are of value in detecting and triaging abnormal smears.
评估焦点定位引导筛查（FPGS）在巴氏染色宫颈阴道涂片计算机辅助初筛中的性能。
共37306例常规连续传统巴氏涂片前瞻性地在FPGS上进行处理。仪器指定为需复查的每张涂片根据使用GS复查工作站获得的结果进行报告。随后，对所有涂片进行传统手工快速筛查，并比较报告的结果。
最初提交至FPGS的涂片中，34004例（91.15%）符合扫描条件。在这些涂片中，系统将7399例（21.8%）分类为无需进一步复查，并将其余26605例（78.2%）列为需复查。在发现的418例细胞异常中，FPGS将409例分类为需复查，9例轻度病变分类在“无需进一步复查”组。总体而言，352例（86%）非典型鳞状细胞（ASC）+被列为高分五分位数，包括102例高级别鳞状上皮内病变（HSIL）或更严重病变中的96例（94%）。定位引导软件在自动选择的视野中识别出378例（92%）排名异常涂片中的细胞异常，对鳞状上皮内病变（SIL）的敏感性>95%。
涂片排名和定位引导筛查功能在检测和分类异常涂片方面具有价值。
