异基因造血干细胞移植后血清巨噬细胞移动抑制因子（MIF）水平
Serum macrophage migration inhibitory factor (MIF) levels after allogeneic hematopoietic stem cell transplantation.
作者信息
Toubai T, Shono Y, Nishihira J, Ibata M, Suigita J, Kato N, Ohkawara T, Tone S, Lowler K P, Ota S, Tanaka J, Asaka M, Reddy P, Imamura M
机构信息
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
Int J Lab Hematol. 2009 Apr;31(2):161-8. doi: 10.1111/j.1751-553X.2007.01016.x. Epub 2007 Dec 12.
Macrophage migration inhibitory factor (MIF) may play an important role in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), as MIF plays an important role to regulate the production of tumor necrosis factor-alpha (TNF-alpha), one of the inflammatory cytokines which induces and exacerbates aGVHD. We examined the association between serum MIF levels and aGVHD vs. chronic GVHD (cGVHD) in allo-SCT patients in this study. We found a significant increase in the peak serum MIF (14.46 ng +/- 1.47 ng/ml) at onset in patients that developed aGVHD (n = 23, P = 0.009). We also found that mean serum MIF levels in patients who developed extensive type cGVHD within 6 months (12.58 +/- 2.18 ng/ml, n = 13) were significantly higher than MIF levels before allo-HSCT (7.86 +/- 1.17 ng/ml, n = 19, P = 0.04). Therefore, we speculated that serum MIF levels increase during the active phase of both aGVHD and cGVHD.
巨噬细胞移动抑制因子（MIF）可能在异基因造血干细胞移植（allo-HSCT）后急性移植物抗宿主病（aGVHD）的发病机制中发挥重要作用，因为MIF在调节肿瘤坏死因子-α（TNF-α）的产生中起重要作用，TNF-α是诱导和加重aGVHD的炎性细胞因子之一。在本研究中，我们检测了allo-SCT患者血清MIF水平与aGVHD和慢性移植物抗宿主病（cGVHD）之间的关联。我们发现发生aGVHD的患者（n = 23，P = 0.009）在发病时血清MIF峰值（14.46 ng +/- 1.47 ng/ml）显著升高。我们还发现，在6个月内发生广泛型cGVHD的患者（12.58 +/- 2.18 ng/ml，n = 13）的平均血清MIF水平显著高于allo-HSCT前的水平（7.86 +/- 1.17 ng/ml，n = 19，P = 0.04）。因此，我们推测在aGVHD和cGVHD的活动期血清MIF水平会升高。
Zotero 插件