Miyata Makoto
Department of Biology, Graduate School of Science, Osaka City University, Japan.
Trends Microbiol. 2008 Jan;16(1):6-12. doi: 10.1016/j.tim.2007.11.002. Epub 2007 Dec 20.
The twelve Mycoplasma species known to glide on solid surfaces all lack surface flagella or pili, and no genes homologous to known motility systems have been found in the five genomes sequenced to date. Recent studies on the fastest of these species, M. mobile, examined novel proteins involved in the gliding mechanism, binding targets on the solid surfaces, energy sources and mechanical characteristics of the movements. Accordingly, I propose a working model for the gliding mechanism, called the centipede (power stroke) model, in which the 'leg' proteins repeat a cycle of binding to and release from the solid surface, using energy from ATP. Another 'inchworm model' suggested from the structural studies of a human pathogen, M. pneumoniae, is also discussed.
已知能在固体表面滑行的12种支原体均缺乏表面鞭毛或菌毛，并且在迄今为止测序的5个基因组中未发现与已知运动系统同源的基因。最近对其中滑行速度最快的物种——运动支原体的研究，探究了参与滑行机制的新型蛋白质、在固体表面的结合靶点、能量来源以及运动的力学特性。因此，我提出了一种滑行机制的工作模型，称为蜈蚣（动力冲程）模型，其中“腿”蛋白利用ATP提供的能量，重复与固体表面结合和从固体表面释放的循环。还讨论了从人类病原体肺炎支原体的结构研究中提出的另一种“尺蠖模型”。
