补充ω-3多不饱和脂肪酸可降低TGR（mRen-2）27大鼠的高血压。
Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats.
作者信息
Jayasooriya A P, Begg D P, Chen N, Mathai M L, Sinclair A J, Wilkinson-Berka J, Wark J D, Weisinger H S, Weisinger R S
机构信息
Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2008 Jan;78(1):67-72. doi: 10.1016/j.plefa.2007.11.001.
To establish the effect of dietary omega-3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in omega-3 PUFA from conception. Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the omega-3 PUFA deficient diet were significantly more hypertensive than those fed the omega-3 PUFA sufficient diet. Perindopril reduced the blood pressure of both omega-3 PUFA-deficient and omega-3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by omega-3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that omega-3 PUFA may reduce hypertension via the renin-angiotensin system.
为确定膳食中ω-3多不饱和脂肪酸（PUFA）对血管紧张素II（ANG II）介导的高血压的影响，从受孕起，将雄性TGR（mRen-2）27（Ren-2）大鼠（具有高ANG II活性的动物）饲养在ω-3 PUFA缺乏或充足的饮食中。每种饮食中的一半动物从出生起就用血管紧张素转换酶抑制剂培哚普利进行治疗。喂食ω-3 PUFA缺乏饮食的Ren-2大鼠比喂食ω-3 PUFA充足饮食的大鼠血压明显更高。培哚普利降低了喂食ω-3 PUFA缺乏和充足饮食的Ren-2大鼠的血压。培哚普利治疗可降低体重、体脂和血浆瘦素水平，但不受ω-3 PUFA供应的影响。鉴于Ren-2大鼠血压升高是由ANG II介导的，这些数据表明ω-3 PUFA可能通过肾素-血管紧张素系统降低高血压。
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