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1
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat Struct Mol Biol. 2008 Jan;15(1):112-3. doi: 10.1038/nsmb1347. Epub 2007 Dec 16.
2
Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.
PLoS One. 2009 Nov 30;4(11):e8044. doi: 10.1371/journal.pone.0008044.
3
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.
Nat Commun. 2018 Oct 19;9(1):4344. doi: 10.1038/s41467-018-06787-w.
5
Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.
Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):680-5. doi: 10.1107/S0907444912007457. Epub 2012 May 17.
6
The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.
Biochim Biophys Acta. 2013 Jul;1834(7):1285-91. doi: 10.1016/j.bbapap.2013.03.018. Epub 2013 Mar 27.
7
Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):266-75. doi: 10.1107/S0907444912045520. Epub 2013 Jan 19.
8
The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J Mol Biol. 2010 May 28;399(1):41-52. doi: 10.1016/j.jmb.2010.03.064. Epub 2010 Apr 9.
10
Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases.
Life Sci Alliance. 2023 Feb 20;6(5). doi: 10.26508/lsa.202201425. Print 2023 May.

引用本文的文献

1
RiSKs in Computational Modeling of Isoform-Selective RSK Inhibitors.
J Chem Inf Model. 2025 Aug 25;65(16):8411-8425. doi: 10.1021/acs.jcim.5c00951. Epub 2025 Aug 12.
2
Capturing Autoinhibited PDK1 Reveals the Linker's Regulatory Role, Informing Innovative Inhibitor Design.
J Chem Inf Model. 2024 Oct 14;64(19):7709-7724. doi: 10.1021/acs.jcim.4c01392. Epub 2024 Sep 30.
3
Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases.
Life Sci Alliance. 2023 Feb 20;6(5). doi: 10.26508/lsa.202201425. Print 2023 May.
5
Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Trends Biochem Sci. 2019 Apr;44(4):300-311. doi: 10.1016/j.tibs.2018.12.002. Epub 2019 Jan 2.
6
Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2.
Oncotarget. 2018 Feb 6;9(76):34200-34212. doi: 10.18632/oncotarget.24409. eCollection 2018 Sep 28.
7
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.
Nat Commun. 2018 Oct 19;9(1):4344. doi: 10.1038/s41467-018-06787-w.
8
RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.
Oncogene. 2018 Jun;37(26):3501-3513. doi: 10.1038/s41388-018-0167-6. Epub 2018 Mar 22.
10
Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG).
PLoS One. 2015 Jun 17;10(6):e0130049. doi: 10.1371/journal.pone.0130049. eCollection 2015.

本文引用的文献

2
Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.
J Biol Chem. 2002 Aug 2;277(31):27733-41. doi: 10.1074/jbc.M202663200. Epub 2002 May 16.
3
The conformational plasticity of protein kinases.
Cell. 2002 May 3;109(3):275-82. doi: 10.1016/s0092-8674(02)00741-9.
4
Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.
Science. 1999 Aug 6;285(5429):886-91. doi: 10.1126/science.285.5429.886.
9
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
Science. 1996 Aug 16;273(5277):959-63. doi: 10.1126/science.273.5277.959.
10
Evidence for two catalytically active kinase domains in pp90rsk.
Mol Cell Biol. 1996 Mar;16(3):1212-9. doi: 10.1128/MCB.16.3.1212.

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