Src激酶与胰腺癌

Src kinase and pancreatic cancer.

作者信息

Hilbig A

机构信息

Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Germany.

出版信息

Recent Results Cancer Res. 2008;177:179-85. doi: 10.1007/978-3-540-71279-4_19.

DOI:10.1007/978-3-540-71279-4_19

PMID:18084959

Abstract

The c-Src non-receptor tyrosine kinase is overexpressed in a large number of human malignancies. It is linked to tumour development and progression to distant metastases by promoting cell proliferation, invasion, and motility. Recently, promising anticancer therapeutics targeting c-Src have been developed that are under clinical investigation.

摘要

c-Src非受体酪氨酸激酶在大量人类恶性肿瘤中过表达。它通过促进细胞增殖、侵袭和迁移，与肿瘤发展及远处转移的进程相关联。最近，已开发出有前景的靶向c-Src的抗癌疗法，正在进行临床研究。