Norman Jonathan, Shapter Joe G, Short Ken, Smith Lachlan J, Fazzalari Nicola L
Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Adelaide, Australia.
J Biomed Mater Res A. 2008 Oct;87(1):196-202. doi: 10.1002/jbm.a.31766.
The ability to assess the risk of fracture, evaluate new therapies, predict implant success and assess the influence of bone remodeling disorders requires specific measurement of local bone micromechanical properties. Nanoindentation is an established tool for assessing the micromechanical properties of hard biological tissues. In this study, elastic modulus and hardness were quantified using nanoindentation for human trabecular bone from the intertrochanteric region of the proximal femur. These properties were demonstrated to be heterogeneous and highly correlated at the intraspicule, interspicule, and interspecimen levels. The results of this study have important implications for current understanding of structure-function relationships throughout the trabecular bone structural hierarchy.
评估骨折风险、评估新疗法、预测植入物成功率以及评估骨重塑障碍的影响，需要对局部骨微力学性能进行特定测量。纳米压痕是评估硬生物组织微力学性能的既定工具。在本研究中，使用纳米压痕对来自股骨近端转子间区域的人松质骨的弹性模量和硬度进行了量化。这些特性在骨小梁内、骨小梁间和样本间水平上表现出异质性且高度相关。本研究结果对于当前对整个松质骨结构层次中结构 - 功能关系的理解具有重要意义。
