HIV-1整合酶抑制剂：最新进展与展望 - Suppr

HIV-1 integrase inhibitors: update and perspectives.

作者信息

Semenova Elena A, Marchand Christophe, Pommier Yves

机构信息

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

出版信息

Adv Pharmacol. 2008;56:199-228. doi: 10.1016/S1054-3589(07)56007-2.

DOI:10.1016/S1054-3589(07)56007-2

PMID:18086413

Abstract

摘要

相似文献

HIV-1 integrase inhibitors: update and perspectives.

Adv Pharmacol. 2008;56:199-228. doi: 10.1016/S1054-3589(07)56007-2.

HIV type 1 integrase inhibitors: from basic research to clinical implications.

AIDS Rev. 2008 Jul-Sep;10(3):172-89.

Resistance to HIV-1 integrase inhibitors: A structural perspective.

Drug Resist Updat. 2010 Aug-Oct;13(4-5):139-50. doi: 10.1016/j.drup.2010.05.001. Epub 2010 Jun 8.

Novel integrase inhibitors for HIV.

Expert Opin Investig Drugs. 2010 Sep;19(9):1087-98. doi: 10.1517/13543784.2010.501078.

Resistance to inhibitors of the human immunodeficiency virus type 1 integration.

Braz J Infect Dis. 2010 Sep-Oct;14(5):513-8.

Characterization and structural analysis of HIV-1 integrase conservation.

AIDS Rev. 2009 Jan-Mar;11(1):17-29.

[Raltegravir: the first HIV integrase inhibitor. Introduction].

Enferm Infecc Microbiol Clin. 2008 Nov;26 Suppl 12:1-2. doi: 10.1016/s0213-005x(08)76565-0.

Integrase inhibitors in the treatment of HIV-1 infection.

J Antimicrob Chemother. 2010 Dec;65(12):2485-8. doi: 10.1093/jac/dkq350. Epub 2010 Sep 18.

Integrase inhibitors.

J HIV Ther. 2005 Dec;10(4):75-8.

L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.

Virology. 2004 Sep 1;326(2):203-19. doi: 10.1016/j.virol.2004.06.005.

引用本文的文献

TAR RNA Mimicry of INI1 and Its Influence on Non-Integration Function of HIV-1 Integrase.

Viruses. 2025 May 11;17(5):693. doi: 10.3390/v17050693.

The Integrase: An Overview of a Key Player Enzyme in the Antiviral Scenario.

Int J Mol Sci. 2023 Jul 29;24(15):12187. doi: 10.3390/ijms241512187.

Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase.

Future Sci OA. 2018 Sep 6;4(9):FSO338. doi: 10.4155/fsoa-2018-0060. eCollection 2018 Oct.

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.

Biotechnol Appl Biochem. 2012 Sep-Oct;59(5):353-66. doi: 10.1002/bab.1034. Epub 2012 Oct 10.

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.

Cell Mol Life Sci. 2012 Apr;69(8):1211-59. doi: 10.1007/s00018-011-0859-3. Epub 2011 Oct 28.

Structure-analysis of the HIV-1 integrase Y143C/R raltegravir resistance mutation in association with the secondary mutation T97A.

Antimicrob Agents Chemother. 2011 Jul;55(7):3187-94. doi: 10.1128/AAC.00071-11. Epub 2011 May 16.

Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6854-7. doi: 10.1016/j.bmcl.2010.08.057. Epub 2010 Aug 17.

Resistance to integrase inhibitors.

Viruses. 2010 Jun 25;2(7):1347-66. doi: 10.3390/v2071347.

Prediction of the interaction of HIV-1 integrase and its dicaffeoylquinic acid inhibitor through molecular modeling approach.

Ethn Dis. 2010 Winter;20(1 Suppl 1):S1-45-9.

Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors.

Antimicrob Agents Chemother. 2010 Sep;54(9):3938-48. doi: 10.1128/AAC.01720-09. Epub 2010 May 17.

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HIV-1 integrase inhibitors: update and perspectives.

作者信息

Semenova Elena A, Marchand Christophe, Pommier Yves

机构信息

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

出版信息

Adv Pharmacol. 2008;56:199-228. doi: 10.1016/S1054-3589(07)56007-2.

DOI:10.1016/S1054-3589(07)56007-2

PMID:18086413

Abstract

摘要

相似文献

HIV-1 integrase inhibitors: update and perspectives.

Adv Pharmacol. 2008;56:199-228. doi: 10.1016/S1054-3589(07)56007-2.

HIV type 1 integrase inhibitors: from basic research to clinical implications.

AIDS Rev. 2008 Jul-Sep;10(3):172-89.

Resistance to HIV-1 integrase inhibitors: A structural perspective.

Drug Resist Updat. 2010 Aug-Oct;13(4-5):139-50. doi: 10.1016/j.drup.2010.05.001. Epub 2010 Jun 8.

Novel integrase inhibitors for HIV.

Expert Opin Investig Drugs. 2010 Sep;19(9):1087-98. doi: 10.1517/13543784.2010.501078.

Resistance to inhibitors of the human immunodeficiency virus type 1 integration.

Braz J Infect Dis. 2010 Sep-Oct;14(5):513-8.

Characterization and structural analysis of HIV-1 integrase conservation.

AIDS Rev. 2009 Jan-Mar;11(1):17-29.

[Raltegravir: the first HIV integrase inhibitor. Introduction].

Enferm Infecc Microbiol Clin. 2008 Nov;26 Suppl 12:1-2. doi: 10.1016/s0213-005x(08)76565-0.

Integrase inhibitors in the treatment of HIV-1 infection.

J Antimicrob Chemother. 2010 Dec;65(12):2485-8. doi: 10.1093/jac/dkq350. Epub 2010 Sep 18.

Integrase inhibitors.

J HIV Ther. 2005 Dec;10(4):75-8.

L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.

Virology. 2004 Sep 1;326(2):203-19. doi: 10.1016/j.virol.2004.06.005.

引用本文的文献

TAR RNA Mimicry of INI1 and Its Influence on Non-Integration Function of HIV-1 Integrase.

Viruses. 2025 May 11;17(5):693. doi: 10.3390/v17050693.

The Integrase: An Overview of a Key Player Enzyme in the Antiviral Scenario.

Int J Mol Sci. 2023 Jul 29;24(15):12187. doi: 10.3390/ijms241512187.

Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase.

Future Sci OA. 2018 Sep 6;4(9):FSO338. doi: 10.4155/fsoa-2018-0060. eCollection 2018 Oct.

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.

Biotechnol Appl Biochem. 2012 Sep-Oct;59(5):353-66. doi: 10.1002/bab.1034. Epub 2012 Oct 10.

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.

Cell Mol Life Sci. 2012 Apr;69(8):1211-59. doi: 10.1007/s00018-011-0859-3. Epub 2011 Oct 28.

Structure-analysis of the HIV-1 integrase Y143C/R raltegravir resistance mutation in association with the secondary mutation T97A.

Antimicrob Agents Chemother. 2011 Jul;55(7):3187-94. doi: 10.1128/AAC.00071-11. Epub 2011 May 16.

Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6854-7. doi: 10.1016/j.bmcl.2010.08.057. Epub 2010 Aug 17.

Resistance to integrase inhibitors.

Viruses. 2010 Jun 25;2(7):1347-66. doi: 10.3390/v2071347.

Prediction of the interaction of HIV-1 integrase and its dicaffeoylquinic acid inhibitor through molecular modeling approach.

Ethn Dis. 2010 Winter;20(1 Suppl 1):S1-45-9.

Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors.

Antimicrob Agents Chemother. 2010 Sep;54(9):3938-48. doi: 10.1128/AAC.01720-09. Epub 2010 May 17.

HIV-1 integrase inhibitors: update and perspectives.

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HIV-1 integrase inhibitors: update and perspectives.

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